Delayed development of brain connectivity in adolescents with schizophrenia and their unaffected siblings

A Zalesky; C Pantelis; V Cropley; A Fornito; L Cocchi; H McAdams; L Clasen; D Greenstein; JL Rapoport; N Gogtay

Journal article

Delayed development of brain connectivity in adolescents with schizophrenia and their unaffected siblings

A Zalesky, C Pantelis, V Cropley, A Fornito, L Cocchi, H McAdams, L Clasen, D Greenstein, JL Rapoport, N Gogtay

JAMA Psychiatry | Published : 2015

DOI: 10.1001/jamapsychiatry.2015.0226

Abstract

IMPORTANCE Abnormalities in structural brain connectivity have been observed in patients with schizophrenia. Mapping these abnormalities longitudinally and understanding their genetic risk via sibship studies will provide crucial insight into progressive developmental changes associated with schizophrenia. OBJECTIVES To identify corticocortical connections exhibiting an altered developmental trajectory in adolescents with childhood-onset schizophrenia (COS) and to determine whether similar alterations are found in patients' unaffected siblings. DESIGN, SETTING, AND PARTICIPANTS Using prospective structural brain magnetic resonance imaging, large-scale corticocortical connectivity was mapped ..

View full abstract

University of Melbourne Researchers

Andrew Zalesky Author

Christos Pantelis Author

Vanessa Cropley Author

Related Projects (2)

TOOLS FOR ANALYSING BRAIN IMAGING DATA IN HEALTH AND DISEASE

This research will develop cutting-edge computational tools and statistical methods to analyse, model and visualise the way in which the hum..

RESEARCH FELLOWSHIP - PROF CHRISTOS PANTELIS

I have established and head the Melbourne Neuropsychiatry Centre within the University of Melbourne. My university position is a research ch..

Grants

Awarded by National Institute of Mental Health

Funding Acknowledgements

This work was supported by the National Institute of Mental Health, Australian National Health and Medical Research Council (Career Development Fellowship GNT1047648 to Dr Zalesky; GNT1066779 and GNT1050504 to Dr Fornito), and the Australian Research Council (Fellowship FT130100589 to Dr Fornito). Dr Pantelis was supported by Australian National Health and Medical Research Council Senior Principal Research Fellowship 628386.